Locking in the best NFL betting odds is the key to maximizing your potential profits sports betting. The smallest total of the week is 33.5 in the Patriots vs Giants game. The biggest over/under of Week 11 also comes in the Commanders vs Cowboys game, where the total is set at 48.5.
Here are the lines in some of Week 12’s other biggest matchups. Looking to the Thanksgiving matchups, the Lions are 7.5-point favorites over the Packers, the Cowboys are laying as many as 11 points (the biggest spread of the week) when they host the Commanders, and the 49ers are 6.5-point favorites in Seattle.
Miami is as big as 10-point favorites in that one. Week 12 in the NFL includes Thanksgiving, which features three games throughout the day, and also the first ever Black Friday game between the Dophins and Jets. NFL Odds Week 12: Lines, Spreads & Totals
